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For some time I have been using the 1 per cent. solution of quinin and urea hydrochlorid, marketed in ampoules, as a local anesthetic, with very satisfactory results.
In the following instance the results might have been very disastrous.
R. C., a white man, aged 20, had just recovered from gonorrhea and was a splendid subject. The ordinary technic for the use of local anesthesia in circumcision was pursued. A rubber catheter was tied around the penis and the quinin solution injected in the line of the proposed skin and mucous membrane incision. The prepuce was removed in the usual way, and the skin sutured to the mucus membrane without the removal of any of the membrane. There was absolutely no sensation, faintness or nausea following the operation. The next morning the penis was very much swollen and of a violet hue; there was. still no sensation. The patient left
Rightor HH. LOCALIZED GANGRENE FOLLOWING THE USE OF QUININ AND UREA HYDROCHLORID. JAMA. 1912;LIX(11):878. doi:10.1001/jama.1912.04270090122019
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