In studying this subject, it is necessary to consider briefly the conditions under which our present system of therapeutics has developed, practically unaided by the fundamental sciences. The science of bacteriology is of comparatively recent origin; it has enabled us to determine not only the nature of some of the infectious agents, but also their distribution in the body, the effect of external agents on them, and to study experimentally their behavior in animals as well. We are at present in the midst of extensive studies in metabolism, so essential in illuminating the dark places in pathologic physiology, by revealing to us the behavior of cells in diseased states. The same is true of the studies now being made in immunity, information directed at the very foundation of disease. Still more recent is the field of experimental therapeutics, where the action of drugs may be observed on animals in which
MILLER JL. HOW MAY THE SCIENCE OF THERAPEUTICS BE ADVANCED?. JAMA. 1912;LIX(12):913–916. doi:10.1001/jama.1912.04270090157001
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