Pemphigus of the conjunctiva is one of the grave diseases of the eye, and was recognized and diagnosed as such as early as 1800. Before this time it was classified with the urticarias and scabies, involving the face and eyes; many others considered it a xerosis of the conjunctiva. When this condition affects the eyes it is usually bilateral, although often unequal in the degree of severity.
There does not seem to be any constant relation between the duration of the skin affection and the development of the eye lesions. Pemphigus may affect the conjunctiva primarily, but this is rather rare, and in some of the cases so reported the lesions of the skin or mucous membranes may have been overlooked.
The course of the disease is usually very slow, extending over a period of years. Samelsohn1 mentions a case that lasted over seven years, with little or no
WEIDLER WB. PEMPHIGUS OF THE CONJUNCTIVA: REPORT OF A CASE WITH MICROSCOPIC FINDINGS. JAMA. 1912;LIX(12):1016–1020. doi:10.1001/jama.1912.04270090260044
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