It has been proved by the work of Dunbar, supplemented by the researches of Kamman, that the pollen of certain grasses, grains or weeds is responsible for the production of pollinosis in susceptible individuals. Not only has it been demonstrated by Dunbar that the pollen of these definite grains and weeds is the sole exciting causative factor, but he has succeeded in isolating from the pollen a certain albuminous portion which is the toxic agent. This poison not only gives rise to the familiar symptoms of pollinosis but is so intense a poison to susceptible individuals that as small a quantity as 1/40,000 mg. will produce a reaction, although a much larger dose is inert in the case of people not susceptible. The susceptibility of different patients varies in degree. It has been demonstrated that a small dose given hypodermatically will quickly kill an animal susceptible to hay fever.
TODD FC. ETHMOIDITIS AS A COMMON SEQUEL (NEVER THE CAUSE) OF POLLINOSIS (HAY FEVER). JAMA. 1912;LIX(12):1090–1093. doi:10.1001/jama.1912.04270090334062
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