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October 5, 1912


Author Affiliations


From the Hospital of the Rockefeller Institute.

JAMA. 1912;LIX(14):1263-1267. doi:10.1001/jama.1912.04270100033011

The subject of syphilitic meningitis, occurring early in the secondary period of the disease, is one which has attracted the attention of occasional observers since 1650, when Guarinoni1 first described the condition. The meningitis usually shows itself first as a disturbance of sight or hearing and may go on to the typical picture of an acute or subacute diffuse meningitis. In Germany, Rumpf,2 Knorre,3 Lang4 and Nonne,5 in France, Gros and Lancereaux,6 Ravaut,7 Fournier,8 Boidin and Weil,9 and in England, Mott10 and Williamson11 have especially called attention to the condition. The advent of salvarsan has, however, given the question a prominence which it never possessed before and has led to a vigorous discussion of the real frequency of its occurrence and of the possibility of salvarsan as a predisposing factor.

In November, 1910, Finger12 in Vienna, in his