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October 5, 1912


JAMA. 1912;LIX(14):1290. doi:10.1001/jama.1912.04270100058021

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C. S., white, man, aged 19, had a chancre in May, 1911. Mucous patches appeared in the mouth one month later. He was treated in Birmingham for six months, with protoiodid of mercury pills, but has had no treatment for the past month, and no further symptoms. Examination showed no evidence of syphilis, except general adenopathy. The heart, eyes, lungs and kidneys were normal.

An intravenous injection of 0.55 gm. salvarsan was given in a hospital at 9 a. m., July 2, 1912. Temperature was 98.6; pulse, 60 and respiration 20. At 10 a. m. the patient complained of headache and vomited 8 ounces of yellow fluid. He slept for one hour; then had large soft bowel movement. Temperature was 105; pulse, 106 and respiration 34. The temperature gradually fell to 101 at 6 p. m. The bowels moved at 6 p m. and again at 12 midnight. The patient

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