It is interesting and instructive to fpllow the history of chloroma. During the ninety years since the first description, frequent changes have developed in the conception of this rather peculiar disease process.
The earlier observers were unable to classify its bizarre clinical picture with the predilection of tumor localization to the cranial and facial bones, the growths of greenish color, and associated painful exophthalmos, deafness and visual disturbances.
The conclusions in vogue were frequently upset as the knowledge of the pathologic anatomy and histology of the greenish tumors, and, later, of the hematology developed, and while in recent years a more careful study of chloroma, which is still a rare disease, has brought a clearer idea of the separate phases, the ultimate nature of the disease process is still unsolved.
The number of examples of chloroma described during the past nine decades, including doubtful cases, numbers about ninety.
BIERRING WL. CHLOROMA: A CLINICAL STUDY OF TWO CASES. JAMA. 1912;LIX(16):1435–1439. doi:10.1001/jama.1912.04270100203007
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