Arteriosclerosis is a penalty of our present civilization and is increasing in frequency so rapidly that any study or contribution leading to its better understanding is well worth while.
For a profitable consideration of the subject, certain fundamental facts of the physics of the circulation and the maintenance of cell life must be recalled. The proper nutrition of the different organs of the body is dependent not only on the functional activity of their own cells, but also on the vital activity of the cells making up the cardiovascular mechanism. Not only must both cell elements remain structurally and functionally intact, but there must be a certain intravascular tension in the arteries, arterioles and capillaries.
I believe no physiologist holds that tissue nutrition can be maintained in the absence of tension. This neither negatives nor loses sight of the principle of osmosis, which, in this connection, might stand for chemical
COLEMAN TD. ARTERIOSCLEROSIS. JAMA. 1912;LIX(22):1933–1937. doi:10.1001/jama.1912.04270110347001
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