A review of the literature on the condition of the protrusion of the eye in connection with scurvy shows that the terms "proptosis" and "exophthalmos," which are synonyms, are used to designate varying degrees of the protrusion. Proptosis is the more commonly used, and specifies the condition when not extreme, whereas exophthalmos is the term always employed to signify the extreme protrusion of the eyeball.
The committee of the American Pediatric Society in its "Collective Investigation of Infantile Scurvy in North America," in 379 cases reported that swelling and protrusion of the eye was noted in forty instances.1 Heubner,2 in his collection of sixty-five cases, states that the orbit was involved four times; and Jacobi,3 in forty cases, four times. In the foregoing cases it is not stated whether the protrusion of the eye was slight, or whether there was a decided exophthalmos. In view of this
DeBUYS LR. EXOPHTHALMOS IN SCURVY. JAMA. 1912;LIX(23):2040–2043. doi:10.1001/jama.1912.04270120025007