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—Some time in 1887 my attention was called to the fact that some pepsins (notably the vegetable product styled "papayotin" by Parke, Davis & Co., and "papoid" by Johnson & Johnson), will digest diphtheritic membranes; it will digest those that are true false-membranes and not infiltrations of the mucous membrane. Acting on this hint I have applied the same treatment to membranes within the larynx, by making a solution ([unk]j to f[unk]j water) and using it very frequently as a spray by means of the hand-ball apparatus. Where the child resists, as is common, I sometimes use an oval speculum. Of course this does not supersede other treatment. I have not had an opportunity to use this often enough to generalize, but I have succeeded in saving every case of croup I have treated since commencing to use it; and I verily believe that, where it is used
Ormsby OB. Treatment of Pseudo-Membranous Laryngitis or Croup. JAMA. 1889;XII(7):251. doi:10.1001/jama.1889.02400840035015
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