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Article
February 23, 1889

EXPERIMENTAL DIABETES.

JAMA. 1889;XII(8):273-274. doi:10.1001/jama.1889.02400850021005

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Abstract

MM. Germain SEE and E. Gley have recently made a report on this subject to the Académie des Sciences. Thus far all attempts to produce diabetes in animals have failed—at least such forms of diabetes as are seen in the human subject. It is well known that irritation of the central end of the vagus nerve gives rise to hyperglycæmia and glycosuria. The experimenters have succeeded in producing permanent irritation of the central end of the right pneumogastric in dogs, and several of the animals have presented not only glycosuria, but true azoturia with notable and rapid emaciation. But this is only one of the elements of diabetes. Dogs have been made glycosuric also by being given daily a quantity of phloridzin. After the first day the urine of these dogs contained, for twenty-four hours, from 10 to 12 per cent, of glucose. The glycosuria ceased with the stoppage of

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