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Article
March 16, 1889

IS THE ANTIPYRIN CRAZE HARMLESS?

JAMA. 1889;XII(11):379-380. doi:10.1001/jama.1889.02400880019003

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Abstract

The number of new drugs constantly recommended to the therapeutist is bewildering. The fertility of the synthetic chemists of Germany seems as exhaustless as the coal beds whence they derive their material. Yet it is questionable whether or not the practice of medicine is benefited by this multiplication of remedies. Paraldehyde, hypnone, urethan and now sulfonal, have all in turn been vaunted for their remarkable hypnotic virtues, and yet our old stand-bys, such as chloral hydrate, continue to maintain their supremacy. Some of the most recent testimony on this point has come from no less an authority than Dr. Huchard, whose conclusions were summarized in our letter from Paris in The Journal of February 23. He has tried sulfonal and found it inert in phthisis, heart disease, subacute articular rheumatism, neuralgia, etc., and therefore believes that its special sphere of action must be in nervous sleeplessness. In his experience it

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