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April 13, 1889

CLINICAL AND EXPERIMENTAL RESEARCHES UPON THE PATHOGENESIS OF FEVER AND THE PATHOGENIC ACTION OF SOLUBLE FERMENTS.A Paper presented before the Academie de Medecine of Paris.

JAMA. 1889;XII(15):517-518. doi:10.1001/jama.1889.02400920013001d
Abstract

[Translated from La Semaine Medicale by Archibald Church, M.D.,of Chicago.]

In bringing forward to-day the second part of the investigations I have undertaken in regard to the pathogenesis of fever, I will recall that M. Hayem three weeks ago presented to the Academy in my name a new chemical substance, pyretogenine, isolated from a microörganism and possessing the singular property, in minute doses, of determining intense and typical attacks of fever.

In the paper describing at length the physiological effects produced by this substance, I announced that I had also experimented with other substances which I proposed to range under the denomination of calorigenes or thermogenes, because they only determined a feeble elevation of temperature without producing the other perturbations characteristic of fever. Further, I announced the existence of frigorigenes, chemical substances of microbian origin, among which was one more energetic than the others that I designated frigorigenine.

I gave

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