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—Polübinsky concludes the eccoprotic action of the drug cannot possibly be attributed to anything like its softening or liquefying fœcal masses, since (a) water, milk, olive oil, and other fluids, when injected into the rectum in similarly small quantities (6 grams or so) fail to excite any motions; (b) when injected in such trifling doses, glycerine is rapidly absorbed by the mucous membrane; (c) stools occurring after glycerine enemata are usually solid and sausage-shaped—that is, show no signs of liquefaction; (d) neither are the masses covered with any watery or slimy layer; (e) stools take place within a short time after the administration of glycerine, while the liquefaction process should necessarily require a comparatively long interval. 2. Glycerine undoubtedly causes a local irritation (probably congestion) of the rectal mucous membrane, since (a) all patients experience a sensation of warmth or some burning in the rectum; (b) there
MEDICAL PROGRESS. JAMA. 1889;XII(18):624–628. doi:10.1001/jama.1889.02400950012003
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