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Since the discovery of the blood corpuscle and the invention of the compound microscope, the attention of hæmatologists has been almost wholly directed to a study of the formed elements of the blood, while its general physical properties and plastic elements have been largely neglected. Especially has this been true of the pathological relations of the blood; a brief reference to our standard works on pathology will show how infrequent are references to changes in the physical properties of the blood, and what is then said upon the subject is mostly confined to the varying phenomena displayed by coagulation. In part this defect has been due to technical difficulties and to the small quantity of blood available for clinical examination.
In 1884, Roy (Journal of Physiology) studied the specific gravity of the blood after a method devised by myself, and applicable to small quantities of blood. The process was extremely
THE SPECIFIC GRAVITY OF HUMAN BLOOD.. JAMA. 1891;XVII(5):193–194. doi:10.1001/jama.1891.02410830029003
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