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Article
August 8, 1891

THE PATHOLOGY OF QUININE AMAUROSIS.

JAMA. 1891;XVII(6):232. doi:10.1001/jama.1891.02410840032006

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Abstract

Dr. De Schweinitz, of Philadelphia, has contributed in the Ophthalmic Review, February, a paper on the results of some experiments undertaken by him to determine the lesion of blindness from quinine. He administered the drug by the hypodermic method in a series of six dogs, using doses varying from 1 grain to 6 grains to each pound of the body-weight. The result of this procedure was a loss of vision in from three to fourteen hours—the exact interval before the onset of blindness not being ascertainable; this symptom was also commonly accompanied with other general disturbance within the same interval of time. In one instance the loss of vision remained practically complete for a period of twenty-nine days in consequence of a single dose of 3¾ grains to the pound of body-weight. The ophthalmoscopic appearances were essentially like those found in man having amaurosis from quinine. In every case the

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