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August 15, 1891

Antipyrin in Whooping-Cough.

JAMA. 1891;XVII(7):273-274. doi:10.1001/jama.1891.02410850037008

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Editor Jour. Amer. Med. Ass'n:  —Though antipyrin has been recommended now for some time in the treatment of pertussis, I am surprised to find still a considerable amount of indifference in regard to its employment, either through ignorance of its beneficial effects or fear of its dangers. Like Sonnenberger, I am almost inclined to regard antipyrin as a specific in this affection, though in using the term specific, I am aware that the action of the drug is exercised not so much upon the disease itself as upon the nervous system, in quieting the reflex spasmodic cough. It seems to me that the conclusions drawn by Ssemtschenko, after a close and careful experimentation, oblige us to consider the real cause of pertussis a bacillus, probably the bacillus of Afanassjew. This bacillus is specific. It is found in the sputum about the fourth day, or even earlier. It multiplies in the

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