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January 7, 1911


Author Affiliations


JAMA. 1911;LVI(1):11-13. doi:10.1001/jama.1911.02560010013003

ECLAMPSIA A DISTINCT DISEASE  The most recent conception of eclampsia is that it is the culmination of toxemia of varied origin. Its crises are manifested by convulsions; explosions of pain, cerebral or substernal; gastric and intestinal irritation; blood or blood-vessel dyscrasia, producing pernicious anemia and hemorrhages, retinal, of mucous membranes, retroplacental, cerebral or general; or as an acute degenerative process of the liver or other organs. We wish to develop this idea to prove that eclampsia is a distinct disease, with a definite pathologic picture, that at times convulsions prove the constant feature, but not invariably so.We may have eclampsia with a typical picture without convulsions. In such cases the eclamptic seizure is manifested (1) by a headache of agonizing, blinding type, in which the patient may become unconscious from the pain; or (2) perhaps as a burning substernal pain, which is, in our experience, an almost constant feature