Dystrophia adiposogenitalis was first described in 1901 by Fröhlich, who asserted that the abnormality was due to diminished function of the pituitary gland. Very few cases had been met in literature until the publication of Harvey Cushing's exhaustive studies, which have thrown considerable light on our knowledge of the function of this gland, especially in its diseased stages. Since then the number of reported cases has increased immensely, and many observers have added a great deal to the studies of this phenomenon.
Cushing1 expressed the hope that many cases of changed hypophyseal secretion would be reported in literature to enable us to get a fair understanding of the different types and subdivide them accordingly. This of course may give a better understanding of the therapy. As stated before, his hopes were fulfilled. Many cases have been reported by competent observers and many facts of value have been added to
BOORSTEIN SW. DYSTROPHIA ADIPOSOGENITALIS (OF FROEHLICH)WITH CLINICAL REPORTS OF TWO CASES. JAMA. 1914;LXIII(2):148–151. doi:10.1001/jama.1914.02570020016008
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