Of late a large amount of work has been done with the Abderhalden test, different tissues being used as substrate in an endeavor to obtain specific reactions which might be of value in diagnosing various obscure conditions. The field of nervous diseases especially has attracted considerable attention. In this respect, for example, dementia praecox and some other nervous disorders have been said to give specific reactions, such tissues as ovary, testicle, brain and other organs being used as substrate.
Abderhalden reports some results which seem to confirm these statements, and his explanation is that in the various diseases which he enumerates a disturbance of the function of certain glands of internal secretion occurs which causes them to produce their secretion in a manner abnormal either in quality or quantity. In these conditions he believes there are mobilized, in the blood of the affected individual, ferments which have a specific action
FALLS FH. PROTEOLYTIC FERMENTS OF THE BLOOD SERUM IN TABES DORSALIS AND GENERAL PARESIS. JAMA. 1916;LXVI(1):22–24. doi:10.1001/jama.1916.02580270026006
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