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Article
January 28, 1911

CHRONIC INFLUENZAL RHINITIS PROMPTLY IMPROVED BY VACCINE THERAPY

JAMA. 1911;LVI(4):264. doi:10.1001/jama.1911.02560040032016
Abstract

The following case of chronic influenzal rhinitis seems to merit report because of the prompt and decisive curative effect of inoculations with heated influenza bacilli.

About four years ago the patient, a physician aged 54, had an attack of influenza and ever since there has been a more or less profuse discharge from the nose, at times so abundant that several handkerchiefs would be soiled during the forenoon, even when nasal washes were frequently used. At the time of the first examination (Aug. 4, 1910) there was a very profuse mucopurulent or purulent nasal discharge which contained many polymorphonuclear leukocytes and some bacteria, including a Gram-staining coccus and a Gram-negative bacillus. On plates of blood-agar (human), the discharge gave rise to some large white colonies composed of staphylococci, and surrounding these, many small dewdrop-like colonies which were difficult to see and which were composed of bacilli. Pure cultures were obtained

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