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August 8, 1914


JAMA. 1914;LXIII(6):485-486. doi:10.1001/jama.1914.02570060045017

In discussing recently1 what has been termed the "emergency function" of the adrenal glands, attention was called to the fact that severe emotions, exemplified in fear, rage and pain, are accompanied by an increased discharge of epinephrin into the blood. The hyperglycemia and the epinephrinemia are both due to nervous discharges. Evidences on record show that these effects may be sufficiently intense to lead to the usual consequence of increase in the sugar-content of the blood, namely, glycosuria. That experimental procedures attended by pain result in the appearance of sugar in the urine was demonstrated many years ago. That pure emotional excitement — fear or rage — will have the same effect was proved when Cannon, Shohl and Wright2 obtained glycosuria in cats by placing them in small cages and permitting dogs to bark at them. Whether or not glycosuria appeared promptly depended on the animal's emotional reaction

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