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February 11, 1911


Author Affiliations


JAMA. 1911;LVI(6):419. doi:10.1001/jama.1911.02560060029011

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In view of the present experimental investigations into the nature and occurrence of the reaction of anaphylaxis, and of the importance of the question to human serotherapy, it is important that clinical record be made of all observations bearing on the phenomenon. The following case of illness, not clearly understood at the time of its occurrence, now appears clearly to have been an instance of anaphylaxis, and is therefore reported.

The subject of the condition, a physician in San Francisco, in the winter of 1900-1 performed an autopsy on a case of bubonic plague. The body was that of a white man, and the history and location of the house in which the illness occurred led to no suspicion as to the nature of the disease. It was, in fact, the first death of a Caucasian that occurred in California from bubonic plague. No precautions were taken in the performance

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