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February 25, 1911


JAMA. 1911;LVI(8):595-596. doi:10.1001/jama.1911.02560080043016

Whenever a pathologist presents a summary of the present status of the problem of cancer etiology, he is more than likely to conclude with a statement to the effect that the solution is up to the biologist. This conclusion rests on the conviction that the growth of cancer cells depends on the same fundamental factors as the growth of normal cells, which have in some way become perverted. The pathologist reasons that when the biologist has shown why normal cells proliferate, and especially why they stop proliferating when certain well-defined limits of growth have been reached, it will be a simple matter to find why sometimes the growth processes are of excessive energy or why they fail to stop at the proper time, and by their lawlessness constitute malignant growths. Cellular biology, therefore, seems to hold the key to the genesis of tumors, and cooperation between its disciples and the

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