Ever since the early experiments which culminated in those of von Mering and Minkowski, showing that removal of the pancreas causes the most profound and extraordinary disturbances in the general metabolism, and more especially in the metabolism of carbohydrates, the search for an explanation has been most active. Notwithstanding the fact that the literature on this subject is enormous and that many side-lights have been cast on the problem, it is still impossible for us to say with any certainty just what we have done in extirpating the pancreas to cause all these changes, and the further the matter is studied the more complex seem the possible relations which exist, not only between this organ and the tissues which are especially concerned in the assimilation and metabolism of the foodstuffs of the body, but also the relations which it bears to the nervous system and to other organs or groups
MACCALLUM WG. THE INTERNAL SECRETION OF THE PANCREAS. JAMA. 1911;LVI(9):655–658. doi:10.1001/jama.1911.02560090027009
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