EXPERIMENTS WITH A TRANSMISSIBLE SARCOMA OF THE FOWL*
PEYTON ROUS, M.D., and JAMES B. MURPHY, M.D.NEW YORKThe fate of tumor cells implanted in the developing embryo has from several points of view a considerable interest. The superficial similarity between neoplastic cells and the cells of embryonic tissue is striking; and it has given rise in part to a widely discussed theory of tumor origin. While this theory well explains a certain class of congenital growths, its more general applicability is questionable. But there is no doubt that the parallel study of embryonic and neoplastic cells can throw much light on important problems of growth.
The implantation of tumor in developing embryos does not seem to have been accomplished heretofore, despite the evident bearing of such an experiment on the supposition that all tumors are of congenital origin. Indeed, it is most difficult with mammalian material, although
TUMOR IMPLANTATIONS IN THE DEVELOPING EMBRYO. JAMA. 1911;LVI(10):741–742. doi:10.1001/jama.1911.02560100033015