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June 2, 1888

Reflex Inhibitory Power of Cocaine.

JAMA. 1888;X(22):689. doi:10.1001/jama.1888.02400480021008

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Mr. E. Hurry Fenwick reports four cases in the Lancet, of May 5, which show that cocaine is possessed of considerable reflex inhibitory power. A series of experiments on decapitated frogs showed that when a 20 per cent. solution was thrown into the cloaca so as to inject the bladder and rectum, reflex excitability was so far diminished that the foot would be retained in a .2 per cent. of sulphuric acid for 20, 30, 60, or even more seconds, while usually the time is about .008 to .015 seconds. In a very painful case of myalgic wry-neck a 20 per cent. solution (gtt. 30) thrown into the urethra caused a diminution of the cramp and stiffness in 40 seconds, and in 60 seconds complete relief, which lasted for some hours. Mr. Fenwick reports also a case of facial neuralgia and flying pains, and one of burning pain in the

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