[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.204.200.74. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 2, 1888

Reflex Inhibitory Power of Cocaine.

JAMA. 1888;X(22):689. doi:10.1001/jama.1888.02400480021008

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

Mr. E. Hurry Fenwick reports four cases in the Lancet, of May 5, which show that cocaine is possessed of considerable reflex inhibitory power. A series of experiments on decapitated frogs showed that when a 20 per cent. solution was thrown into the cloaca so as to inject the bladder and rectum, reflex excitability was so far diminished that the foot would be retained in a .2 per cent. of sulphuric acid for 20, 30, 60, or even more seconds, while usually the time is about .008 to .015 seconds. In a very painful case of myalgic wry-neck a 20 per cent. solution (gtt. 30) thrown into the urethra caused a diminution of the cramp and stiffness in 40 seconds, and in 60 seconds complete relief, which lasted for some hours. Mr. Fenwick reports also a case of facial neuralgia and flying pains, and one of burning pain in the

First Page Preview View Large
First page PDF preview
First page PDF preview
×