It is the object of this note to describe certain ameboid phenomena observed in the cells of rat and mouse sarcomas when cultivated in vitro, and to suggest that these phenomena probably play an important part in the infiltrative and metastatic growth of tumors.
We have employed in this study Burrows'1 modification of Harrison's2 technic, as applied by us3 to rats and mice.
Since rat and mouse sarcomas do not differ essentially from one another in their behavior when cultivated in vitro, we shall confine our description, for the sake of clearness, to the various changes observed in the cells of a mouse sarcoma growing in mouse plasma. The edges of a freshly implanted piece of tissue, examined under the microscope, are sharply defined and free from projecting cells. The tissue itself looks compact and homogeneous. Twelve hours later the edges of the tissue are beset with
LAMBERT RA, HANES FM. MIGRATION BY AMEBOID MOVEMENT OF SARCOMA CELLS GROWING IN VITRO: AND ITS BEARING ON THE PROBLEM OF THE SPREAD OF MALIGNANT GROWTHS IN THE BODY. JAMA. 1911;LVI(11):791–792. doi:10.1001/jama.1911.02560110005002
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