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Article
September 19, 1914

METABOLISM IN FEVER

JAMA. 1914;LXIII(12):1035-1036. doi:10.1001/jama.1914.02570120055021
Abstract

The construction of the ideal dietary schedule for fever patients will not be accomplished until the nature of the disturbance of metabolism in diseases attended with rise of body temperature is clearly ascertained. It is agreed that the increase in total metabolism in fever is ordinarily associated with increases in protein metabolism. The cause of the latter, however, has given rise to much speculation and contradictory views. At least three explanations of the higher catabolism of protein have been ventured. First, it has been ascribed to the high temperature. We have previously referred to the investigations of Graham and Poulton1 on this point. Living on a ration abundant in carbohydrates whereby they easily reached a low plane of nitrogenous equilibrium, these investigators subjected themselves to heated steam sufficient to raise their body temperature to as high as 40 C. (104 F.). During this artificial state of high temperature no

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