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June 16, 1888


JAMA. 1888;X(24):757-758. doi:10.1001/jama.1888.02400500025008

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Sulfonal, a New Opiate—Bicarbonate of Potash in Iodoform Poisoning—Attempt to blow up a Hospital— Gluten Bread—Dwarfing by Factories and Tenements—Treatment of Spinal Abscesses—Virchow.

Professor Kast announces his discovery of a new opiate. He calls it "sulfonal" and it belongs to the group of the so-called di-sulphates, and in an oxydation product of the union of "acthylmerkuptan" with acetone, in crystals without taste or smell, easily dissolvable. It has the property of inducing sleep in invalids, particularly in nervous people and those affected with heart disease, but not in healthy subjects. Prof. Kast has observed that "sulfonal" produces sleep without altering the pressure of the blood in any degree. An accident led to the discovery of the sleep producing property of "sulfonal." It had been administered to some dogs with quite a different intention and the animals first were affected as if with intoxication, and afterwards fell into a deep sleep.

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