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Article
March 18, 1916

THE HISTORY OF INTRAVENOUS AND SUBCUTANEOUS ADMINISTRATION OF DRUGS

JAMA. 1916;LXVI(12):856-860. doi:10.1001/jama.1916.02580380006003
Abstract

With the revival of interest in the treatment by drugs, and the epoch-making studies of pharmacology and experimental therapeutics in the past ten or twenty years, the administration of substances by subcutaneous or intravenous injection is being practiced on a large scale, both in experimental work on animals and in the treatment of patients. An inquiry into the historical development of these more exact and certainly more efficacious methods of drug administration may therefore be of considerable and timely interest. Curiously enough, although in the domain of surgery we find the names of numerous individuals perpetuated by being tagged to all kinds of minor and unimportant manipulations and operations, in the domain of internal medicine and more especially in connection with medicinal treatment, the origin of some of our most important and life-saving procedures and remedies is shrouded in obscurity. It is really our duty, therefore, to ascertain as far

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