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March 18, 1911

Induced Cell-Reproduction and Cancer. The Isolation of the Chemical Causes of Normal and of Augmented, Asymmetrical Human Cell Division.

JAMA. 1911;LVI(11):840. doi:10.1001/jama.1911.02560110062038

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The object of this ambitious book is to present the details obtained by the study of living human cells under the microscope and the bearing of the results especially on the causation of cancer. The living cells, principally blood-cells, "are examined by placing them, under a cover-glass, on the surface of a film of jelly, which may contain dissolved in it any substance we may wish to experiment with, and which has, while in a molten condition, been poured on the microscopic slide and allowed to set there." The substance used in making the jelly is agar. It proving impossible to prepare permanent specimens by fixation of the jelly films, a rapid and ingenious method of photomicrography was worked out so that the appearances presented by the cells under observation could be reproduced accurately at any moment. The illustrations in the book have been made from photographs thus obtained.


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