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March 25, 1911


JAMA. 1911;LVI(12):882-885. doi:10.1001/jama.1911.02560120022011

Clinically and pathologically typhoid meningitis is of especial interest, because of the common occurrence of nervous symptoms during the course of a severe typhoid, and because of the several types of meningitis that occasionally occur. R. Cole1 has critically reviewed the subject of typhoid meningitis, adding a number of new cases to a list based on bacteriologic findings. He divides the cases into three groups:

  1. Meningism. Symptoms of meningitis are present but there are no meningeal lesions and no direct relation between the bacteria and the symptoms. This condition is produced by the toxins in other specific fevers.

  2. Serous meningitis of Quincke, in which there are symptoms of meningitis; the brain shows, microscopically, edema and round-cell infiltration, and a serous exudate is present, in which is found the typhoid organism.

  3. Suppurative or purulent typhoid meningitis.

For purposes of more definite classification we prefer to subdivide Class 3 into purulent typhoid

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