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March 25, 1916


JAMA. 1916;LXVI(13):960-961. doi:10.1001/jama.1916.02580390030020

There is a growing belief that the pituitary body is concerned in some way with the functions of growth. The uncertainty is engendered by the circumstance that much of the earlier support for this relationship has been derived from clinical observations and incidental evidence. These are always liable to a considerable degree of error or correction, owing to the uncontrollable conditions and the numerous variables which enter into the indirect study of patients. More exact methods of investigation may always be expected to correct or revise the suggestions obtained from the bedside, the clinic or the necropsy room. In the case of the pituitary functions it has unfortunately happened that the results of experimental interference have remained somewhat in dispute. Perhaps one reason for this lies in the uncertainty which attends the use of the word "growth." The experiments of Gudernatsch and others1 have emphasized the fact that in discussing