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For some time now I have been using antipyrin and antifebrin in nervous headaches. My attention was first called to the use of antipyrin in these cases by Prof. Walter S. Haines, M.D. I have found a few cases of sick headache that would yield to this remedy, but generally in persons of nervous temperament. My cases have all been non-febrile. The remedy is prescribed in 5-grain doses every hour until the headache ceases. Often one powder is sufficient, and rarely are more than two or three required.
I have been told that antipyrin has none of its depressing effect upon the heart in non-febrile cases. Such is not my observation. In frail nervous patients, especially in delicate females of nervous temperament, I find that antipyrin does disturb the heart's action, even in 3-gr. and 5-gr. doses. This effect of antipyrin followed notwithstanding the good effect of relieving the headache.
CARTER JMG. USE OF ANTIPYRIN AND ANTIFEBRIN FOR HEADACHES.. JAMA. 1888;XI(6):196–197. doi:10.1001/jama.1888.02400580016002e
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