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October 10, 1914

CANCER VACCINE AND ANTICANCER GLOBULINS AS AN AID IN THE SURGICAL TREATMENT OF MALIGNANCY

JAMA. 1914;LXIII(15):1258-1265. doi:10.1001/jama.1914.02570150014004
Abstract

During the past six years I have devoted considerable time to the study of specific cancer therapy, and various phases of these investigations have been published from time to time as definite facts of scientific interest were obtained. The work is based on the theory1 first published in 1910, which states that through altered chemical nature the normal tissue-cell changes into the malignant cell.

If a malignant cell is chemically different in its protein content from a normal tissue-cell it should be possible to sensitize an animal to one protein and not the other. That this is the case has been proved and it has also elicited knowledge concerning a new and extremely interesting form of sensitization to which has been given the term "transitory sensitization."

Formerly I have purposely refrained from mentioning the therapeutic results obtained in these investigations in the belief that at least from three to five

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