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April 1, 1916


JAMA. 1916;LXVI(14):1020-1021. doi:10.1001/jama.1916.02580400026013

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This case of purpura hemorrhagica, in a man aged 28, is instructive in the showing of a prompt response to treatment with normal horse serum.

History:  —The patient had measles during childhood. In his eighteenth year he suffered from an illness diagnosed as nephritis, from which he recovered in three weeks. While never robust, he had had no other diseases, and assurance is positive that he was never subject to abnormal bleeding of any kind. There was no knowledge of hemorrhage in any member of his family. The present illness began the middle of December, 1915, with symptoms diagnosed as the grip. The temperature was from 103 to 104, and there were prostration, cough, and a mucopurulent expectoration. Under his physician's care he improved to some extent, when, January 9, he began to bring up large quantities of thin, bloody sputum. Two days later blood appeared in the urine, the

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