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September 8, 1888


JAMA. 1888;XI(10):347-348. doi:10.1001/jama.1888.02400620023004

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Surgeon P. O. W. Halley, of the Indian Medical Service, records some cases, in the Indian Medical Gazette of June, that well illustrate the action of some of the recently introduced antipyretics. These cases were nearly all of the adynamic type, and were treated throughout with small doses of tincture of digitalis as a cardiac tonic, and with quinine during the remissions, and stimulants as required. In one case antifebrin produced a very marked fall of temperature twice, of 5.2° and 4.4° respectively, without causing symptoms of depression otherwise than a slight slowing of the pulse and reduction of pulse-tension. When given in brandy it produced very little depressing effect, and Mr. Halley says that a dose of 7 grains is usually effectual. In a second case, severe and complicated with pneumonia, antifebrin caused less depression than antipyrin, and lowered the temperature as effectually. The average time taken by

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