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In looking up the literature on the subject, I find but few mortalities reported following the use of collargol, but a number of cases in which great damage has been done the kidney as shown by subsequent operation. The pathologic findings in these cases have been similar but the theories as to the cause of the destructive action of the remedy differ with the various observers.
There is also great divergence of opinion as to the toxicity of this drug; some claiming that it has an irritating and even cauterizing effect, while others assert that it has no injurious effect whatever on the pelvic mucosa, the tubular epithelium or other tissues of the kidney. There are still others who seem to be of the opinion that the kidney cells have the power of ingesting and distributing the drug throughout the entire kidney, in other words, the theories are that the
CROWELL AJ. COLLARGOL IN PYELOGRAPHYWITH REPORT OF AN INTERESTING CASE. JAMA. 1914;LXIII(16):1387–1389. doi:10.1001/jama.1914.02570160053017
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