The first recorded case of albumose in considerable amount in the urine with accompanying destructive lesion of bone was reported by Henry Bence-Jones1 of London, before the Royal Society of London, in 1874.
The urine was from a male patient, a grocer, aged 45, who dated his illness from a violent strain in vaulting from a cavern, accompanied at the time by violent pain in the chest, and who, after sixteen months' illness, died. This case occurred in the practice of a Dr. Maclntire. At the autopsy Bence-Jones remarked, "I saw that the bony structure of the ribs was cut with the greatest ease and the bodies of the vertebræ were capable of being sliced off with a knife." Microscopically, their interior presented "granular matter, oil globules, nucleated cells, constituting the bulk of the mass—a few caudate cells and blood-disks extravasated largely among the other cells, and giving the
KING JM. MULTIPLE MYELOMA WITH ALBUMOSURIA: REPORT OF A CASE. JAMA. 1911;LVI(15):1092–1094. doi:10.1001/jama.1911.02560150014004
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