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Until recently the term typhoid fever was applied to a complexus of symptoms, well recognized and defined, and accompanied by a peculiar lesion of the intestinal tract. As now understood says Dr. Bayard Holmes, in a paper recently read before the Chicago Medical Society, typhoid fever means the invasion of a non-pyogenic microörganism, however that invasion may take place—whether by way of the intestinal or respiratory tract, and whether or not accompanied by the classical symptoms that characterize abdominal typhus. He says typhoid fever is the infection of the typhoid bacillus, and the direct consequences of such infection. There may be symptoms and results due to infection by other microörganisms, but these he regards as accidental complications, and are not parts of the typhoid disease.
He claims that when the typhoid bacillus invades the human organism, the inflammation of the lymph-glands caused by the irritation of the bacillus and its
SECONDARY MIXED INFECTION IN TYPHOID FEVER. JAMA. 1888;XI(13):453–454. doi:10.1001/jama.1888.02400650021004
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