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Article
November 3, 1888

EXOPHTHALMIC GOITRE AND ITS TREATMENT BY TINCTURE OF STROPHANTHUS.Read before the Mississippi Valley Medical Society, at St. Louis, Mo., September 25, 1888.

Author Affiliations

PROFESSOR OF DISEASES OF THE NERVOUS SYSTEM IN THE WOMAN'S MEDICAL COLLEGE; LECTURER ON THE PRACTICE OF MEDICINE IN RUSH MEDICAL COLLEGE, SPRING COURSE, CHICAGO, ILL.

JAMA. 1888;XI(18):626-628. doi:10.1001/jama.1888.02400700014001e
Abstract

In this paper I desire to invite your attention anew to the more prominent features in the clinical history and diagnosis of exophthalmic goitre, and suggest its treatment by strophanthus.

The eyes, the thyroid gland, and the circulatory system are usually all perverted by the morbific process in this disease. The order of their sequence varies, but usually the circulatory disorders are first manifested. These consist of increased frequency of the pulse, palpitation, and dilatation of the arteries. The pulse in a mild case is about 100, but it may reach such a point in frequency as is impossible to count. The frequency varies with the emotional condition. Indeed, the impression made by the heart's action is one of intense nervous excitement in the cases generally. In the early stages the heart sounds are normal, but anæmic murmurs may soon be found, and later along, organic murmurs—organic murmurs that have

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