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Article
April 29, 1916

EXPERIMENTAL STUDIES IN THE PRODUCTION OF CHRONIC GASTRIC ULCER

Author Affiliations

NEW YORK

From the Pathological Laboratory of the Mount Sinai Hospital.

JAMA. 1916;LXVI(18):1382. doi:10.1001/jama.1916.02580440020010
Abstract

Recently streptococci have been isolated from typical indurated ulcers of the stomach, and these when injected into the blood stream of animals have caused ulcerations of the stomach.1

The present investigation has for its object the production of an ulcer with a chronically inflamed and indurated edge which exhibits no tendency toward healing. It seemed to us that if organisms isolated from similar ulcers from human stomachs were injected directly into recent defects in the stomach wall of animals, the opportunity for the production of characteristic chronic ulcers would be enhanced.

In a number of animals the healing of a surgically produced defect was first studied. These defects were made by excising tissue from the stomach wall down to and including part of the muscularis, and measured from 1 to 2 cm. in diameter. It was shown that such defects healed completely in from one to two weeks. The

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