In 1850 a moderate giant, 6 feet 2 inches in height, married a woman of diabetic tendencies who later developed true diabetes, from which she died. This marriage gave rise to a family of three apparently normal daughters, of whom one still lives, one died at the age of 62 of carcinoma, and the third died of pneumonia following the puerperium. None of the three showed during her life any tendency, so far as we can now recognize such tendency, toward internal glandular disturbance. All three of them married. The oldest, No. 3 in Figure 1, had a family consisting of six individuals, of whom one, No. 9, had exophthalmic goiter, No. 11 harelip, No. 12 chalky degeneration of the teeth with a tendency to diabetes, and No. 14, who was born blind and puny, developed a sarcoma of the face, and died in his first year of life. No.
TIMME W. ENDOCRINOPATHIC INHERITANCE. JAMA. 1916;LXVI(19):1438–1441. doi:10.1001/jama.1916.02580450004002
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