For some years past, pharmaceutical houses have put out in tablet form an enormous number of combinations of drugs of real or fancied value. In many instances the combinations are not suited to the tablet form and it is not surprising that many of these tablets do not conform to the composition that is claimed for them. It is not to be inferred that the manufacturers wilfully put up products that are false to label, but rather that many of the combinations are pharmaceutical impossibilities. That is to say. it is pharmaceutically impossible—or at least, commercially impracticable—to manufacture, in tablet form, some of the combinations that are listed in the manufacturers' catalogues.
These tablet-combinations have been offered to the medical profession primarily because such products are considered as "business-getters" and the manufacturers seem to have tried to outvie one another in the number of combinations which they offer physicians. In
UNRELIABLE PHARMACEUTICAL PRODUCTS. JAMA. 1911;LVI(18):1334–1335. doi:10.1001/jama.1911.02560180028016
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