Since salvarsan and neosalvarsan are no longer obtainable, the use of various mercury salts intravenously has become more widespread. This method of treating syphilis is not new, the use of mercuric chlorid having been introduced by Baccelli in 1893. It has been revived from time to time, and each time abandoned because obliteration of the veins has been produced. This is a definite disadvantage and a very possible danger; I myself have seen it eventuate in a local slough and edema of the forearm.
Any method of administration, therefore, which promises to prevent or decrease the frequency of vein obliteration is to be welcomed. The method which I am reporting is so simple that it is quite possible that it has been described before; it certainly is not in general use, and I have not been able to find a description of it in the literature. It is infinitely more
Nixon PI. THE INTRAVENOUS USE OF MERCURIC CHLORID: A NOTE ON A NEW METHOD OF ADMINISTRATION, WITH SPECIAL REFERENCE TO PREVENTION OF VEIN OBLITERATION. JAMA. 1916;LXVI(21):1622. doi:10.1001/jama.1916.25810470004018d
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