The purpose of this paper is to present, as concisely as is consistent with clearness, the chief points in the chemical changes which occur in an organism suffering with nephritis. The aim is to confine the remarks to those non-suppurative forms of nephritis, which are termed Bright's disease, rather than the various suppurative or other focal lesions due to localization of bacteria. If, throughout the paper, many of the statements seem dogmatic, the necessity for brevity must be held accountable. Lengthy argument would only seem to render less clear a subject which, at best, is but in its developmental stages. The point of view presented is taken to represent that which is most modern and most widely accepted.
It is proposed to take up the subject in this sequence:
Review of normal metabolism of proteins, fats, carbohydrates and salts, in reference to excretion of intermediate and end-products by the kidneys.
KARSNER HT. THE CHEMISTRY OF NEPHRITIS. JAMA. 1911;LVI(20):1452–1454. doi:10.1001/jama.1911.02560200020012
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