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August 3, 1889


JAMA. 1889;XIII(5):163-164. doi:10.1001/jama.1889.02401040019003

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On the Influence of Aniline and of the Toluidines on the Respiratory Capacity of the Blood, and on the Temperature.  —In an article in C. R. Soc. de Biologie, Jan. 5, 1889, p. 10, E. Wertheimer and E. Meyer publish the results of experiments which show that chloride of aniline and of toluidine injected into the veins of a dog (30 centigr. per kilo. animal) cause within a few minutes an abundant transformation of hæmoglobin into methæmoglobin (proven spectroscopically). Also in vitro methæmoglobin originates very rapidly in the blood after introducing aniline or toluidine. These substances produce in the dog a moderate decrease of carbonic acid in the blood and considerable decrease of oxygen. The latter is for aniline (7.3 instead of 23.1 vol. per cent.), and for metatoluidine (6.8 instead of 20.4 per cent. o), much more considerable than for paratoluidine (13.5 instead of 23.1 per cent. o), or

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