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August 10, 1889


JAMA. 1889;XIII(6):196-198. doi:10.1001/jama.1889.04440040016004

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On Injections of Testicular Liquid.—In the Société de Biologie de Paris M. Variot reported three experiments which had been made to ascertain the physiological action of fresh testicular liquid injected subcutaneously, after the manner of Brown-Séquard. The liquid used was obtained by crushing and triturating the testicles of a rabbit or of a guinea-pig in 10 cubic centimetres of distilled water. After separating this liquid from the residual pulp by simple decantation two Pravaz syringes of it were injected under the skin of the abdomen at a dose, the injections being repeated every forty-eight hours.

Variot operated on three men, of 25, 56, and 68 years, respectively, who were much debilitated from various causes. The effects produced in these three cases were satisfactory from the first, and continued so after subsequent injections. Sixteen injections were made in all. No harmful symptoms requiring any attention were noticed. The injections proved

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