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December 12, 1914

GASTRO-INTESTINAL STUDIESIV. DIRECT EVIDENCE OF THE SECRETION OF A GASTRIC JUICE OF CONSTANT ACID CONCENTRATION BY THE HUMAN SUBJECT

JAMA. 1914;LXIII(24):2088-2092. doi:10.1001/jama.1914.02570240006002
Abstract

The question of gastric acidity has received considerable attention in recent years. It has been demonstrated quite conclusively, for example, that the phrase "the normal gastric juice of man contains about 0.2 per cent, of hydrochloric acid" can no longer go unquestioned. On the basis of older experimental evidence a rather high acidity (from 0.5 to 0.6 per cent.) was accorded the gastric juice of such lower animals as the cat and dog, whereas man was found to remain content with an acidity in the vicinity of 0.2 per cent. More recent experiments,1 however, indicate that the actual acidity of the gastric juice of man is very similar (from 0.4 to 0.5 per cent.) to the gastric juice of the cat and the dog.

Pawlow,2 on the basis of experiments made principally by his colleague Ketscher, enunciated the belief that "the gastric juice as it flows from the

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